Most digestive supplements focus exclusively on probiotics while ignoring the upstream problem: insufficient enzyme activity. If you don't produce enough protease, lipase, or amylase, the food reaching your large intestine is partially undigested — and that's what feeds the gas-producing bacteria responsible for bloating and discomfort. MassZymes addresses both ends of the equation simultaneously, which is why it consistently outperforms single-focus probiotic products in our assessment.
Our Scores
Ingredient Analysis
Protease ADS (100,000 HUT)
The highest-potency protease blend we've seen in any digestive enzyme supplement. 100,000 HUT (Hemoglobin Units on Tyrosine) is substantially above the typical 10,000–30,000 HUT in standard formulas. Breaks down protein into absorbable amino acids, dramatically reducing the undigested protein that feeds gas-producing bacteria.
Lipase (3,000 FIP)
Fat-digesting enzyme that supports complete fat breakdown. Insufficient lipase is the primary cause of fat-related bloating and the characteristic loose stools that follow high-fat meals. 3,000 FIP is in the upper range for commercial supplements.
Amylase (50,000 DU)
Carbohydrate-digesting enzyme. Breaks down starches before they reach the large intestine, reducing fermentation by colonic bacteria. Particularly valuable for people who experience bloating after carbohydrate-heavy meals.
Bromelain & Papain
Pineapple-derived bromelain and papaya-derived papain provide additional proteolytic activity across a broader pH range than animal-derived enzymes alone. They're effective in both the acidic stomach environment and the alkaline small intestine.
L. acidophilus
One of the best-studied probiotic strains, with evidence for lactase production (helping those with lactose sensitivity), pathogen competitive exclusion, and immune modulation. The 3 billion CFU dose is appropriate for maintenance; higher doses are available in dedicated probiotic supplements.
Prebiotic Complex
Inulin and FOS (fructooligosaccharides) feed the probiotic strains after delivery to the colon, supporting colonization. Prebiotic inclusion distinguishes MassZymes from enzyme-only supplements that don't support the microbiome they're trying to restore.
Pros and Cons
What We Like
- Highest enzyme potency of any supplement we've reviewed
- Addresses both enzyme deficiency AND microbiome simultaneously
- Prebiotic inclusion supports probiotic colonization
- Third-party tested for potency and purity
- 365-day money-back guarantee — the best in the industry
- Vegan-friendly, no artificial additives
Limitations
- Premium price point vs. individual enzyme supplements
- Probiotic CFU count is lower than dedicated probiotic products
- Requires refrigeration after opening for optimal potency
Who Is MassZymes Best For?
MassZymes is particularly valuable for people who experience bloating, gas, or digestive discomfort consistently after meals — regardless of what they eat. If you react poorly to proteins, fats, and carbs equally, insufficient enzyme activity rather than microbiome dysbiosis alone is likely the root cause. MassZymes addresses both.
It's also excellent for people over 50, as digestive enzyme production naturally declines with age, and for those with known low stomach acid (hypochlorhydria).
Pricing and Guarantee
MassZymes is available in single ($49), 3-pack ($41/bottle), and 5-pack ($35/bottle) configurations. All purchases include BiOptimizers' exceptional 365-day money-back guarantee — the longest in the supplement industry and a strong signal of the company's confidence in the product.
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See Full Gut Ranking →Frequently Asked Questions
Can I take MassZymes if I have IBS?
MassZymes can be beneficial for IBS — particularly IBS-D (diarrhea-predominant) and IBS-B (bloating-predominant) — where incomplete digestion is a contributing factor. However, IBS has multiple subtypes and causes. Consult a gastroenterologist for a complete evaluation before relying on supplements alone.
Do I take MassZymes with every meal?
Yes — digestive enzymes work only when food is present. Take 1–3 capsules at the beginning of each meal. You can start with 1 capsule and increase based on your response. Taking enzymes on an empty stomach has no digestive benefit.
Is MassZymes suitable for vegetarians?
Yes — MassZymes uses plant-derived and microbial-derived enzymes, making it suitable for vegetarians and vegans. The capsule shells are also plant-based (HPMC).